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Friday, August 19, 2016

FDA Docs: Smoking Beagles and Breast Cancer?

The FDA/nicotine/smoking/tobacco rabbit hole goes very deep.  I have cherry picked away at some of it and left crumbs for you to follow.  The going gets tough for a while so hang in there...

From the FDA Response to NicoPure (bottom of page #10):

"Although the FDA recognized that completely switching to e-cigarettes may reduce the risk of tobacco-related disease for individuals currently smoking conventional cigarettes—one of the deadliest products ever brought to market—it found that e-cigarettes still pose a number of significant health and safety risks. "

Okay, so out of the box the FDA agrees we have "less risk" with e-cigarettes.

Is that a health claim?

Of course, there are still a "number of significant health and safety risks."

So the next few posts are going to examine, in as painless a detail as possible, what the FDA says (next paragraph or so in the response):

"First, nicotine is “one of the most addictive substances used by humans,” 81 Fed. Reg. at 28,988, and “a powerful pharmacologic agent that acts in the brain and throughout the body,” Surgeon General’s Report (1988) at 14 (AR 1183). “[N]icotine is psychoactive (‘mood altering’) and can provide pleasurable effects,” and “causes physical dependence characterized by a withdrawal syndrome that usually accompanies nicotine abstinence.” Id. E-cigarettes can deliver as much nicotine as conventional cigarettes—sometimes more. 81 Fed. Reg. at 29,031."

(Gee, seems like Colorado weed falls into the "psychoactive mood altering and pleasurable" category as well... but that's another story I guess.)

Perhaps, but the first reference (81 Fed. Reg. at 28988, is a (Ref. 7) link to page 29095 #7).  This is, of course the FDA's citing the FDA's own deeming regulation.

The referenced document can be found here (the listed link appears to be broken but you can search the title of the document: "Institute of Medicine of the National Academies, ‘‘Ending the Tobacco Problem: A Blueprint for the Nation,’’ 2007").

This document is quite long and on the bottom of page #5 it says "First, nicotine is “one of the most addictive substances used by humans...”

However, this document also says this (underlines my own):

"The number of studies that have assessed the role of specific genes in smoking behavior continues to grow. The work of Malaiyandi and colleagues (2005), for example, suggests that cytochrome P450 (CYP) 2A6, the liver enzyme which mediates the conversion of nicotine to cotinine, may play an important role in smoking (Malaiyandi et al. 2005). 
In a review of recent genetic studies of nicotine dependence, Li (2006) presents evidence that several genes may be implicated in nicotine dependence (Li 2006). 
The results of these studies suggest that specific subgroups of smokers have a significantly higher probability of abstinence when they use nicotine patches, nicotine nasal spray, and bupropion treatment (Lerman et al. 2002, 2004; Swan et al. 2005). .... "

So maybe smoking is genetic?  (See this and this.)  This is a fascinating subject if you delve into it...

Next the 1988 Surgeon General report is here:

This is hundreds of pages in length but there are many interesting gems to be found besides the FDA's ominous quotes:

  • We discover, for example, that on page 106 much can be said about the chronic smoking of male beagles and their testicles.
  • We also discover that smoking in human women results to some degree is earlier menopause and lower incidences of breast cancer.
  • Smokers weigh less.  Wonder if this has anything to do with the current obesity crisis?

How interesting...

Perhaps nicotine is not all so bad after all.  I am certain that vaping to reduce breast cancer might be an attractive alternative to a mastectomy.

All in all the FDA is regurgitating decades of what every vaper already knows: smoking is bad, or, more specifically, smoking (combustion) tobacco is bad.  Decades of federal dollars flooding the coffers (I wonder if those federal dollars are as addicting as nicotine).

And yes, there can be negative effects of nicotine as well be most of what is said relates to animals.  Humans are often only "observed."

But these document often use "smoking" and "tobacco" and "nicotine" in interchangeable ways leading one to suspect that perhaps these three things have been considered the "same thing" until vaping came along.

Clearly this is all cherry picking: both on my part and the FDAs.

There are thousands of pages here and I am certain you can probably get those pages to say just about anything you wanted to regarding nicotine...

Just remember the 

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